spontaneous fetal loss before 24 weeks gestation ND </= 500G
causes
- 1st trimester
- chromosomal abnormalities
- PCOS
- APS (antiphospholipid syndrome)
- endocrine disorder (untreated DM or thyroid disease)
- uterine abnormalities (submucosal fibroid, subseptate uterine, endometrial polyp)
- infection: TORCHES
- 2nd trimester
- Cervical incompetence
- Asherman syndrome
- bacterial vaginosis
- uterine abnormalities (higher in 2nd trimester)
- thrombophilias
- infection: TORCHES
- bactrerial vaginosis
1. threatened miscarriage
- PV bleed
- viable fetus
- os close
- symptoms of pregnancy
- uterus correspond to date
mx:
- ABC
- remove POC at os
- put prostin for priming for cervical os 3hours prior to arrange for ERPOC
2. inevitable miscarriage
- PV bleed (a lot)
- abdominal pain
- os open but no POC seen
- viable fetus
- uterus correspond to date
3. incomplete miscarriage
- PV bleed (a lot)
- abdominal pain
- os open with POC seen
- non viable fetus, thick ET, retained POC in uterus
- uterus smaller than date
4. complete miscarriage
- PV bleed (gush of blood) with POC
- abdominal pain
- os close
- uterus empty, normal endometrial lining
- uterus smaller than date
5. missed miscarriage
- asymptomatic
- os close
- non viable fetus
- uterus smaller than date
- BhCG may still be produce by placenta
mx:
- repeat US after 7-14 days if in doubt.
- then arrange for ERPOC.
- TCA stat if passed out POC, PV bleeding, fever.
- psychological support and counselling.
6. septic miscarriage
- PV bleeding and discharge
- abdominal pain
- history of amniocentesis
- os open with POC
- cervical motion tenderness
- adnexal tenderness
- uterus smaller than date
- fetus non viable, thick ET, retained POC in uterus
mx: psychological support and counselling
7. recurrent miscarriage
more or equal to 3 consecutive miscarriage
- risk factor
- woman is ≥35 years of age and the man ≥40 years of age
- smoking and alcohol
- antiphospholipid syndrome
mx:
- investigate the cause; DM, thyroid ds, renal ds, SLE
- rule out uterine/cervical abnormalities
- cervical cerclage for cervical incompetence
- Pregnant women with antiphospholipid syndrome should be considered for treatment with low-dose aspirin plus heparin to prevent further miscarriage